Clinician resources

Please see our latest communication to healthcare providers regarding upcoming changes to our Early Years range of formulas, including some improved amino acid profiles, an additional indication, and new product codes.

A simplified explanation of the published data on Complex MSD medical foods for maple syrup urine disease (MSUD).

Acquaint yourself with Nutricia’s products for inherited metabolic disorders. The poster provides a visual overview, the quick reference booklet gives a bit more detail about each product, and the full Nutricia product reference guide provides detailed nutrition and ingredient information.

• Metabolic Product Poster
• Quick Reference Booklet for Metabolic Products
• Nutricia Product Reference Guide

A free service to help your patients obtain insurance coverage and faster access to Nutricia products. Find 3 easy steps to get started.

• Learn More: Product Coverage & Access Assistance
• Email Navigator Directly: NutriciaNavigator@Nutricia.com

A quick guide and practical tips on how to manage maternal PKU.

Approximate US household measurements available for the following products:

• PKU Periflex Early Years & Anamix Early Years
• PKU Periflex Junior Plus
• TYR Anamix Next

These slide decks provide a simple, scientific overview of rare metabolic disorders and their management. These decks can be used to educate new metabolic healthcare providers, students/interns, or families with high medical literacy.

• Phenylketonuria (PKU)
• Glutaric Aciduria Type 1 (GA-1)
• Homocystinuria (HCU)
• Isovaleric Acidemia (IVA)
• Maple Syrup Urine Disease (MSUD)
• Methylmalonic Acidemia (MMA)
• Propionic Acidemia (PA)
• Tyrosinemia Type 1 (TYR)
• Medium-chain acyl-CoA dehydrogenase (MCAD)
• Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD)
• Very-long-chain acyl-CoA dehydrogenase (VLCAD)

Free web-based e-book and Apple/Android app of the 3rd edition of this publication, which provides a systematic and practical approach to the diagnosis of and therapies for metabolic diseases.

• To view the e-book, please visit vademetab.org 

Request samples for your patients or clinic.

• Online sample request https://www.nutriciametabolics.com/shop/HCPsample 

Due to the medical food status, consent from a healthcare provider is required for patients/caregivers to purchase or obtain a sample of any metabolic products directly through Nutricia. As a healthcare provider, you can provide consent for your patient by completing this form.

These are interactive tools for Healthcare Professionals to help calculate the amount of Nutricia metabolic product needed to achieve a desired amount of protein equivalent for individual patients. The tool can then be used to compare macro and micro nutrients to the DRIs (as of 2010). (Microsoft® Excel files – note, please right click on the link and “Save Target As…” to save this to your desktop and then open through Excel).

• Periflex LQ & Periflex Advance DRI Calculator
• Maxamum DRI Calculator
• UCD Anamix Junior DRI Calculator
• Monogen DRI Calculator
• Phlexy-Vits DRI Calculator

An anticipatory guidance tool, developed by The Children’s Hospital of Colorado, Denver, to aid healthcare professionals in the treatment of patients with PKU. Materials and topics include: Clinic Encounter Check Lists, Experience and Thoughts, Teaching Aids and Handouts and other resources. All chapters have been developed as an anticipatory guidance tool with patient education and improved patient compliance as its main goal. We welcome you to print, individualize, and add to any and all of the sections. Whatever your approach, we hope this educational tool assists you in your clinic setting.

• Chapter One
• Chapter Two
• Chapter Three
• Chapter Four

Practical guidelines on how to incorporate PhenylAde PheBLOC, a medical food containing large neutral amino acids, into the PKU diet.

Select Clinical References for PKU Periflex Early Years

• MacDonald A, et al. Specific prebiotics in a formula for infants with phenylketonuria. Mol Genet Metab. 2011;104 Suppl:S55-9. PubMed 

Select Clinical References for Periflex Junior Plus

• Buist NRM, et al. A new amino acid mixture permits new approaches to the treatment of phenylketonuria. Acta Paediatr Suppl. 1994;407:75-7. PubMed 
• Cleary MA, et al. Randomised controlled trial of essential fatty acid supplementation in phenylketonuria. Eur J Clin Nutr. 2006;60(7):915-20. PubMed 

Select Clinical References for PKU Maxamum (previously named XPhe Maxamum)

• Brown MC, et al Economic impact of feeding a phenylalanine-restricted diet to adults with previously untreated phenylketonuria. J Intell Disabil Res. 1999; 43:30-7. PubMed 
• Cleary MA, et al. Magnetic resonance imaging in phenylketonuria: reversal of cerebral white matter change. J Pediatr. 1995; 127:251-255. PubMed 
• Wardley BL, Taitz LS. Clinical trial of a concentrated amino acid formula for older patients with phenylketouria (Maxamum XP). Eur J Clin Nutr. 1988; 42:81-86. PubMed 

Select Clinical References for Phlexy-10

• MacDonald A, et al. Protein substitutes for PKU: What’s new? J Inherit Metab Dis. 2004; 27:363-371. PubMed 
• Moats RA, et al. Brain phenylalanine concentrations in phenylketonuria: Research and treatment of adults. Pediatrics. 2003;112(6): 1575-9. PubMed 
• Rohr FJ, et al. Acceptability of a new modular protein substitute for the dietary treatment of phenylketonuria. J Inherit Metab Dis. 2001; 24:623-630. PubMed 

Select Clinical References for PhenylAde PheBLOC LNAA

• Yano S, et al. Melatonin and dopamine as biomarkers to optimize treatment in phenylketonuria: effects of tryptophan and tyrosine supplementation. J Pediatr. 2014;165:184-9. PubMed 

Select Clinical References for GlutarAde Junior

• Stauss KA, et al. Safety, efficacy and physiological actions of a lysine-free, arginine-rich formula to treat glutaryl-CoA dehydrogenase deficiency: focus on cerebral amino acid influx. Mol Genet Metab. 2011;104(1-2):93-106. PubMed 
• Strauss, KA et al. Glutaric acidemia type 1: Treatment and outcome of 168 patients over three decades. Mol Genet Metab. 2020;131:325-40. PubMed 

Select Clinical References for Complex MSD Products

• Strauss KA, et al. Classical maple syrup urine disease and brain development: principles of management and formula design. Mol Genet Metab. 2010;99(4):333-45. PubMed 
• Strauss KA, et al. Branched-chain α-ketoacid dehydrogenase deficiency (maple syrup urine disease): Treatment, biomarkers, and outcomes. Mol Genet Metab. 2020;129:193-206. PubMed 

Select Clinical References for Monogen

• Cormack, BE et al. Use of Monogen for pediatric postoperative chylothorax. Ann Thorac Surg. 2004; 77(1):301-5. PubMed 
• Ficicioglu C, et al. Very long-chain acyl-CoA dehydrogenase deficiency: The effects of accidental fat loading in a a patient detected through newborn screening. J Inherit Metab Dis. 2009;32 Suppl 1:S187-90. PubMed 
• Lessen R. Use of Skim Breast Milk for an Infant with Chylothorax. ICAN (2009); 1 (6):303-10. Sage Journals 
• Ng PC, et al. Deceptive hyperbilirubinaemia in a newborn with familial lipoprotein lipase deficiency. J Paediatr Child Health. 2001;37:314-6. PubMed