GI/Allergy

 

Healthcare Professional Tools

Flowcharts/Guidelines

  • Cow Milk Allergy in Infancy Dietary Management Flow Chart

    This flow chart is an evidence-based tool that may be used as a decision-making guide for clinicians. It illustrates options for the dietary management of CMA for infants (0-12 months), and where hypoallergenic nutrition (Pepticate & Neocate) fits in. The flow chart poses guiding questions and considerations to ensure patients’ nutrition needs are being met.

  • Eosinophilic Esophagitis (EoE) Management Flow Chart

    This flow chart is an evidence-based tool that may be used as a decision-making guide for clinicians. It illustrates possible signs and symptoms that can help identify EoE patients, options for the dietary management of EoE, and where elemental nutrition (Neocate) fits in. The flow chart poses guiding questions and considerations to ensure patients’ nutrition needs are being met. It includes a list of the Neocate family of products.

  • FPIES Dietary Management Flow Chart

    This flow chart is an evidence-based tool that may be used as a decision-making guide for clinicians. It illustrates options for the dietary management of FPIES, and where elemental nutrition (Neocate) fits in. The flow chart poses guiding questions and considerations to ensure patients’ nutrition needs are being met. It includes a list of the Neocate family of products.

  • Short Bowel Syndrome Management Flow Chart

    This flow chart illustrates different options for the dietary management of Short Bowel Syndrome and where amino acid-based formulas fit in. It is an evidence based tool that may be used as a decision making guide for clinicians. The flow chart includes a list of the Neocate® family of products.

Reference Library

  • Cow Milk Allergy (CMA) & Gut Microbiota

    Clinical References for Neocate related to Cow Milk Allergy (CMA) and Gut Microbiota

    • Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83:677-86. Full Text
    • Fox AT, Wopereis H, Van Ampting MTJ, et al. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial. Clin Transl Allergy. 2019;9:5. Full Text
    • Wopereis H, van Ampting MTJ, Cetinyurek-Yavuz A, et al. A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow's milk allergic infants: a randomized controlled trial. Clin Transl Allergy. 2019;9:27. Full Text
    • Sorensen K, Cawood AL, Gibson GR, et al. Amino Acid Formula Containing Synbiotics in Infants with Cow's Milk Protein Allergy: A Systematic Review and Meta-Analysis. Nutrients. 2021;13. Full Text
  • Cow Milk Allergy (CMA)

    Publications in which Neocate was studied or used in dietary management or research related to CMA

    • Fierro V, Valluzzi RL, Banzato C, et al. A well-tolerated new amino acid-based formula for cow's milk allergy. Immun Inflamm Dis. 2020;8:140-9. Fierro PubMed Full Text
    • Fox AT, Wopereis H, Van Ampting MTJ, et al. A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial. Clin Transl Allergy. 2019;9:5. Fox 2019 PubMed Full Text
    • Payot F, Lachaux A, Lalanne F, et al. Randomized trial of a yogurt-type amino acid-based formula in infants and children with severe cow's milk allergy. J Pediatr Gastroenterol Nutr. 2018;66:135-40. Payot PubMed Full Text
    • Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83:677-86. Candy 2018 Journal Full Text
    • Berni Canani R, Nocerino R, Frediani T, et al. Amino acid-based formula in cow's milk allergy: long-term effects on body growth and protein metabolism. J Pediatr Gastroenterol Nutr. 2017;64:632-8. Berni Canani Journal Full Text
    • Fox AT, Wopereis H, Van Ampting MT, et al. Amino acid-based formula including specific synbiotics modifies the gut microbiota and reduces clinical symptoms in non-IgE mediated cow’s milk allergic infants. Oral abstract presented at EAACI Congress. 17-21 June; Helsinki, Finland. Allergy. 2017;72:102(0122). Fox 2017A Journal Abstract
    • Fox A, van Ampting M, Oude Nijhuis M, et al. Amino acid-based formula with synbiotics modifies gut microbiota in non-IgE mediated cow’s milk allergic infants. Poster presented at ASCIA 28th Annual Conference. 13-15 September; Auckland, New Zealand. Internal Medicine Journal. 2017;47:15(P35). Fox 2017B Journal Abstract
    • Harvey BM, Eussen SRBM, Harthoorn LF, et al. Mineral intake and status of cow's milk allergic infants consuming an amino acid-based formula. J Pediatr Gastroenterol Nutr. 2017;65:346-9. Harvey 2017 Journal Full Text
    • Sorensen K, Fry C, Allford A, et al. Longitudinal study shows improved nutrient intakes and growth with an amino acid formula for children ≥1y with cow's milk allergy and related conditions. Poster presented at EAACI Annual Congress. Jun 17-21; Helsinki, Finland. Allergy. 2017;72:523(0899). Sorensen 2017 Journal Abstract
    • Wopereis H, Van Ampting M, Candy DCA, et al. Gut microbiota composition of non-IgE mediated cow's milk allergic infants before and after dietary management with a synbiotics-supplemented amino acid-based formula. Poster presented at AAAAI Annual Meeting. 4-6 March; Atlanta, GA. J Allergy Clin Immunol. 2017;139:AB53(168). Wopereis Journal Abstract
    • Michaelis LJ, Wopereis H, van Ampting MTJ, et al. An amino acid-based formula with synbiotics affects faecal microbiota in non-IgE mediated cow’s milk allergic infants. EAACI Annual Congress. Jun 11-15; Vienna, Austria. Allergy. 2016;71(S102):58(114). Michaelis Journal Abstract
    • Harvey B, Harthoorn L, Burks A. Mineral status of infants requiring dietary management of cow's milk allergy by using an amino acid-based formula. 5th WCPGHAN. October 5-8; Montreal, Quebec. J Pediatr Gastroenterol Nutr. 2016;63:S400(1172). Harvey 2016A Journal Abstract
    • Harvey BM, Harthoorn LF, Burks AW. Mineral status of infants requiring dietary management of cow's milk allergy by using an amino acid-based formula. 4th EAACI FAAM. October 13-15; Rome, Italy. 2016:(PD57). Harvey 2016B Congress Abstract
    • Candy DCA, van Ampting MTJ, Oude Nijhuis MM, et al. Dietary management of non-IgE mediated cow's milk allergic infants with a synbiotics-supplemented amino acid-based formula: effects on faecal microbiota and clinical symptoms. Poster presented at WCPGHAN Meeting. Oct 5-8; Montréal, Québec. 2016. Candy 2016A Journal Abstract
    • Candy DCA, van Ampting MTJ, Garssen J, et al. Dietary management of non-IgE mediated cow's milk allergic infants with a synbiotics-supplemented amino acid-based formula: effects on faecal calprotectin, eosinophilic cationic protein and a1-antitrypsin concentrations. Poster presented at 4th EAACI FAAM. Oct 13-15; Rome, Italy. 2016:(PP067). Candy 2016B Congress Abstract
    • Cordova J, Sriram S, Patton T, et al. J Pediatr Gastroenterol Nutr. 2015;62:140-4. Cordova Journal Full Text
    • Nowak-Węgrzyn A, Czerkies LA, Collins B, et al. Evaluation of hypoallergenicity of a new, amino acid-based formula. Clin Pediatr. 2015;54:264-72. Nowak-Węgrzyn 2015 PubMed Abstract
    • Burks AW, Harthoorn LF, van Ampting MTJ, et al. Synbiotics-supplemented amino acid-based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol. 2015;26:316-22. Burks 2015 Journal Full Text
    • Burks AW, Harthoorn L, van Ampting M, et al. Functional effects, including effects on gut microbiota, of an amino acid-based formula with synbiotics in cow’s milk allergic infants. EAACI Annual Congress. June 7-11; Copenhagen, Denmark. Allergy. 2014;69:574(1639). Burks 2014A Journal Abstract [Purchase]
    • Burks WA, Harthoorn LF, Langford JE, et al. Functional effects of an amino-acid based formula with synbiotics in cow’s milk allergic infants. Oral presentation presented at 3rd PAAM. Oct 17-19; Athens, Greece. Clin Transl Allergy. 2014;4:7(O23). Burks 2014B Journal Abstract
    • Colson D, Kalach N, Soulaines P, et al. Anthropomorphic variations according to clinical pattern in cow's milk allergic children. Poster presented at AAAAI Annual Meeting. February 28-March 4; San Diego, CA. J Allergy Clin Immunol. 2014;133:AB65(231). Colson 2014 Journal Abstract
    • Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino acid–based formula with synbiotics. Pediatr Res. 2014;75:343-51. Harvey 2014 Journal Full Text
    • 23. Petrus NC, Schoemaker AF, van Hoek MW, et al. Remaining symptoms in half the children treated for milk allergy. Eur J Pediatr. 2014. Petrus PubMed Abstract
    • Nowak-Wegrzyn A, Czerkies L, Saavedra JM. Evaluation of hypoallergenicity of a new, amino-acid based formula. EAACI-WAO Congress. June 22-26; Milan, Italy. Allergy. 2013;68:115-88(307). Nowak-Wegrzyn 2013 Journal Abstract [Purchase]
    • Colson D, Michaud B, Soulaines P, et al. Long term nutritional outcome of children fed by an amino-acid formula. AAAAI Annual Meeting. February 22-26; San Antonio, TX. J Allergy Clin Immunol. 2013;131:AB98(355). Colson 2013 Journal Abstract
    • Miller J. “Like taking away his lifeline”: recognizing and addressing the role of food as a sensory regulation strategy in children with autism. ICAN: Infant Child & Adolescent Nutrition. 2013;5:274-82. Miller Journal Abstract
    • Epifanio M, Spolidoro JV, Soder RB, et al. Gray-scale and color Doppler ultrasound findings in children with cow's milk allergy. AJR Am J Roentgenol. 2011;196:W817-22. Epifanio Journal Full Text
    • Muñoz Urribarri A, Delgado Godos A, Castillo Durán R, et al. [Case report: allergy to cow's milk protein]. Rev Gastroenterol Peru. 2011;31:183-7. Muñoz Urribarri PubMed Abstract
    • Dupont C, Soulaines P, Lapillonne A, et al. J Pediatr Gastroenterol Nutr. 2010;50(4):463-4. Dupont 2010 Journal Full Text
    • Koksal B, Ozbek O, Hosnut F, et al. Food protein induced proctocolitis in five infants. XXIX EAACI Congress. June 2010; London, UK. Allergy. 2010;65(420(1117). Koksal Journal Abstract
    • Srinivasan P, Brandler M, D'Souza A, et al. J Perinatol. 2010;30(6):431-3. Srinivasan PubMed Abstract
    • Becker PJ. ICAN: Infant Child & Adolescent Nutrition. 2009;1(4):214-9. Becker Journal Abstract
    • Hill DJ, Murch SH, Rafferty K, et al. The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review. Clin Exp Allergy. 2007;37:808-22. Hill 2007 PubMed Abstract
    • Maloney J, Nowak-Wegrzyn A. Educational clinical case series for pediatric allergy and immunology: allergic proctocolitis, food protein-induced enterocolitis syndrome and allergic eosinophilic gastroenteritis with protein-losing gastroenteropathy as manifestations of non-IgE-mediated cow's milk allergy. Pediatr Allergy Immunol. 2007;18(4):360-7. Maloney PubMed Abstract
    • Faber MR, Rieu P, Semmekrot BA, et al. Acta Paediatr. 2005;94(10):1514-5. Faber PubMed Abstract
    • Hernandez-Trujillo VP, Nguyen WT, Belleau JT, et al. Cow's milk allergy in a patient with hyper-IgE syndrome. Ann Allergy Asthma Immunol. 2004;92:469-74. Hernandez-Trujillo 2004 PubMed Abstract
    • Hernandez-Trujillo VP, Belleau JT, Nguyen WT, et al. Beneficial effect of an amino-acid based formula for neonatal eosinophilic folliculitis associated with hyper-IgE syndrome and cow's milk allergy. J Allergy Clin Immunol. 2003;111(2):S228-. Hernandez-Trujillo 2003 Journal Abstract
    • Dupont C, de Boissieu D. [Treatment of severe allergy to cow's milk proteins by Neocate®]. Allerg Immunol (Paris). 2002;34:85-90. Dupont 2002 PubMed Abstract
    • Kanny G, Moneret-Vautrin DA, Flabbee J, et al. [Use of an amino acid-based formula in the treatment of cow's milk protein allergy and multiple food allergy syndrome]. Allerg Immunol (Paris). 2002;34:82-4. Kanny PubMed Abstract
    • Kirjavainen PV, Arvola T, Salminen S, et al. Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? Gut. 2002;51:51-5. Kirjavainen PubMed Full Text
    • Moneret-Vautrin DA, Hatahet R, Kanny G. [Milk protein hydrolysates: hypoallergenic formulas and extensively hydrolyzed formulas: allergologic basis for their use in prevention and treatment of cow's milk allergy]. Arch Pediatr. 2001;8:1348-57. Moneret-Vautrin PubMed Abstract
    • Sicherer SH, Noone SA, Koerner CB, et al. Hypoallergenicity and efficacy of an amino acid-based formula in children with cow's milk and multiple food hypersensitivities. J Pediatr. 2001;138:688-93. Sicherer PubMed Abstract
    • de Boissieu D, Dupont C. Time course of allergy to extensively hydrolyzed cow's milk proteins in infants. J Pediatr. 2000;136:119-20. de Boissieu 2000 PubMed Abstract
    • D'Netto MA, Herson VC, Hussain N, et al. J Pediatr. 2000;137:480-6. D'Netto PubMed Abstract
    • Ammar F, de Boissieu D, Dupont C. [Allergy to protein hydrolysates. Report of 30 cases]. Arch Pediatr. 1999;6:837-43. Ammar PubMed Abstract
    • Dupont C, Niggemann B, Binder C, et al. Early introduction of an amino acid-based vs protein hydrolysate formula in children with cow milk allergy: a randomised multicentre trial. ESPGHAN 32nd Annual Meeting. June 2-5; Warsaw, Poland. J Pediatr Gastroenterol Nutr. 1999;28:589(17). Dupont 1999 Journal Abstract
    • Sotto D, Tounian P, Baudon JJ, et al. [Allergy to cow's milk protein hydrolysates: apropos of 8 cases]. Arch Pediatr. 1999;6:1279-85. Sotto PubMed Abstract
    • Isolauri E, Sutas Y, Salo MK, et al. Elimination diet in cow's milk allergy: risk for impaired growth in young children. J Pediatr. 1998;132:1004-9. Isolauri 1998 PubMed Abstract
    • Bruel H, Le Luyer B, Chabrolle JP, et al. Arch Pediatr. 1998;5:461-2. Bruel Journal (Purchase French Full Text)
    • de Boissieu D, Matarazzo P, Dupont C. Allergy to extensively hydrolyzed cow milk proteins in infants: identification and treatment with an amino acid-based formula. J Pediatr. 1997;131:744-7. de Boissieu 1997 PubMed Abstract
    • Lake AM. Beyond hydrolysates: use of L-amino acid formula in resistant dietary protein-induced intestinal disease in infants. J Pediatr. 1997;131(5):658-60. Lake PubMed (citation only)
    • Murray ND, Kaufman SS, Vanderhoof JA. Growth of infants with cow milk allergy who were treated with Neocate®. ASPEN 20th Clinical Congress. Jan 14-17, 1996; Washington, DC. 1996:387. Murray PubMed (citation only)
    • Vanderhoof JA, Kaufman SS, Murray MD, et al. Evaluation of Neocate in infants with milk protein induced colitis. NASPGN 1995 Congress. 1995;21:331(30). Vanderhoof 1995 Journal Abstract
    • Sampson HA, James JM, Bernhisel-Broadbent J. Safety of an amino acid-derived infant formula in children allergic to cow milk. Pediatrics. 1992;90:463-5. Sampson Journal Abstract
  • Multiple Food Protein Intolerance (MFPI)

    Clinical References for Neocate related to Multiple Food Protein Intolerance (MFPI)

    • Kaczmarski M, Zur E, Kondej-Muszynska K. Therapeutic and nutritional applications of amino acid-based elemental formulas in children with food allergies: a preliminary report. Post Dermatol Alergol. 2012;29(2):86-93.
    • Noimark L, Cox HE. Nutritional problems related to food allergy in childhood. Pediatr Allergy Immunol. 2008;19(2):188-95. PubMed
    • Isolauri E, Sampson HA. Use of an amino acid based formula in the management of cow’s milk allergy and multiple food protein intolerance in children. J Allergy Clin Immunol. 2004;113(2):S154, abstract 518. Abstract
    • Latcham F, Merino F, Lang A, et al. A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy. J Pediatr. 2003;143(1):39-47. PubMed
    • Hill DJ, Heine RG, Cameron DJ, et al. The natural history of intolerance to soy and extensively hydrolyzed formula in infants with multiple food protein intolerance. J Pediatr. 1999;135(1):118-21. PubMed
    • Hill DJ, Cameron DJ, Francis DE, et al. Challenge confirmation of late-onset reactions to extensively hydrolyzed formulas in infants with multiple food protein intolerance. J Allergy Clin Immunol. 1995;96(3):386-94. PubMed
  • Short Bowel Syndrome (SBS)

    Clinical References for Neocate related to Short Bowel Syndrome (SBS)

    • Leechawengwongs E, Tison BE, Gopalakrishna GS, et al. Does short bowel syndrome increase the risk of food allergy and eosinophilic gastrointestinal disease? Observations in Shah-Waardenburg syndrome. J Allergy Clin Immunol. 2013;131(1):251-5. Full Text
    • Woods CW, Ayers K, Turner C, et al. ICAN: Infant Child & Adolescent Nutrition. 2012;5(1):32-6. Abstract
    • Sigalet D, Boctor D, Brindle M, et al. Elements of successful intestinal rehabilitation. J Pediatr Surg. 2011;46(1):150-6. PubMed
    • De Greef E, Mahler T, Janssen A, et al. The influence of Neocate in paediatric short bowel syndrome on PN weaning. J Nutr Metab. 2010;2010. Full Text
    • Theyskens C, Dams A. Enteral nutrition regimen for neonates with short bowel syndrome. Nutrition. 2008;24(10):1045-7. PubMed
    • Hasosah M, Lemberg DA, Skarsgard E, et al. Congenital short bowel syndrome: a case report and review of the literature. Can J Gastroenterol. 2008;22(1):71-4. Full Text
    • Serrano MS, Schmidt-Sommerfeld E. Nutrition support of infants with short bowel syndrome. Nutrition. 2002;18(11-12):966-70. Full Text
    • Andorsky DJ, Lund DP, Lillehei CW, et al. Nutritional and other postoperative management of neonates with short bowel syndrome correlates with clinical outcomes. J Pediatr. 2001;139(1):27-33. PubMed
    • Veereman-Wauters GA, Van Elsacker E, Hoffman I, et al. Successful avoidance of total parenteral nutrition by administration of an amino acid-based enteral formula (Neocate®) in infancy. Digestive Disease Week - 101st Annual AGA Meeting. May 21-4, 2000; San Diego, CA. Gastroenterology. 2000;118(4;Suppl 2:1 of 2):A777(4159). Full Text
    • Brewster D, Kukuruzovic R, Haase A. Short bowel syndrome, intestinal permeability and glutamine. J Pediatr Gastroenterol Nutr. 1998;27(5):614-6. PubMed
    • Bines J, Francis D, Hill D. Reducing parenteral requirement in children with short bowel syndrome: impact of an amino acid-based complete infant formula. J Pediatr Gastroenterol Nutr. 1998;26(2):123-8. PubMed
    • Murray ND, Kaufman SS, Vanderhoof JA. Use of Neocate® in infants with short bowel syndrome. ASPEN 20th Clinical Congress. Jan 14-17, 1996; Washington, DC. 1996;6):397. PubMed
  • Food Protein-Induced Enterocolitis Syndrome (FPIES)

    Clinical References for Neocate related to Food Protein-Induced Enterocolitis Syndrome (FPIES)

    • Mane SK, Bahna SL. Clinical manifestations of food protein-induced enterocolitis syndrome. Curr Opin Allergy Clin Immunol. 2014;14(3):217-21. Full Text
    • Järvinen KM, Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome (FPIES): current management strategies and review of the literature. J Allergy Clin Immunol Pract. 2013;1(4):317-22.e4. PubMed
    • Anand RK, Appachi E. Case report of methemoglobinemia in two patients with food protein-induced enterocolitis. Clin Pediatr (Phila). 2006;45(7):679-82. PubMed
    • Vanderhoof JA, Murray ND, Kaufman SS, et al. Intolerance to protein hydrolysate infant formulas: an underrecognized cause of gastrointestinal symptoms in infants. J Pediatr. 1997;131(5):741-4. PubMed
    • Kelso JM, Sampson HA. Food protein-induced enterocolitis to casein hydrolysate formulas. J Allergy Clin Immunol. 1993;92(6):909-10. PubMed
  • Atopic Dermatitis

    Clinical References for use of Neocate related to Atopic Dermatitis

    • Kaczmarski M, Wasilewska J, Lasota M. Hypersensitivity to hydrolyzed cow's milk protein formula in infants and young children with atopic eczema/dermatitis syndrome with cow's milk protein allergy. Rocz Akad Med Bialymst. 2005;50:274-8. PubMed
    • Leung TF, Ma KC, Cheung LT, et al. A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis. Pediatr Allergy Immunol. 2004;15(6):558-61. PubMed
    • Arvola T, Moilanen E, Vuento R, et al. Weaning to hypoallergenic formula improves gut barrier function in breast-fed infants with atopic eczema. J Pediatr Gastroenterol Nutr. 2004;38(1):92-6. PubMed
    • Isolauri E, Tahvanainen A, Peltola T, et al. Breast-feeding of allergic infants. J Pediatr. 1999;134(1):27-32. PubMed
    • Kuzminskiene R, Vaiciulioniene N. Nutritional management of multiple food protein intolerance induced severe atopic dermatitis in infants. XIX Nordic Congress on Allergology. August 10-13, 1996; Helsinki, Finland. Allergy. 1996;51(Suppl 32):75(P94). Abstract (available for purchase)
    • Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97(1 Pt 1):9-15. PubMed
  • Gastroesophageal Reflux (GER)

    Clinical References for Neocate related to Gastroesophageal Reflux (GER)

    • Borrelli O, Mancini V, Thapar N, et al. Cow's milk challenge increases weakly acidic reflux in children with cow's milk allergy and gastroesophageal reflux disease. J Pediatr. 2012;161(3):476-81 e1. PubMed
    • Thomson M, Wenzl T, Fox A, et al. Effect of an amino acid-based milk - Neocate® - on gastro-oesophageal reflux in infants assessed by combined intraluminal impedance/pH. Pedriatr Asthma Allergy Immunol. 2006;19(4):205-13. Abstract
    • Heine R, Cameron D, Francis D, et al. Effect of amino acid-based formula on gastroesophageal reflux in infants with persistent distress. J Allergy Clin Immunol. 2003;111(2):S102. Abstract
    • Miele E, Staiano A, Tozzi A, et al. Clinical response to amino acid-based formula in neurologically impaired children with refractory esophagitis. J Pediatr Gastroenterol Nutr. 2002;35(3):314-9. PubMed
    • Hill DJ, Heine RG, Cameron DJ, et al. Role of food protein intolerance in infants with persistent distress attributed to reflux esophagitis. J Pediatr. 2000;136(5):641-7. PubMed
    • Miele E, Staiano R, Troncone A, et al. Clinical response to amino acid-based enteral formula in neurologically impaired children with refractory esophagitis. J Pediatr Gastroenterol Nutr. 1999;28(5):561(68). Abstract
    • Hill DJ. Multiple food protein intolerance (MFPI) as a cause of reflux oesophagitis in infancy: results of a pilot study. J Allergy Clin Immunol. 1998;101(1):S89. Missing
    • Hill DJ, Catto-Smith ACS, Cameron DJS, et al. Is multiple food protein intolerance (MFPI) the cause of "reflux oesophagitis" in distressed infants. J Allergy Clin Immunol. 1996;97(1 Pt 3):336-. Abstract
    • Kelly K, Lazenby A, Yardley J, et al. Elemental diet therapy in pediatric patients with chronic reflux symptoms: improvement of esophageal histopathology. Digestive Disease Week - 95th Annual AGA Meeting. May 15-18, 1994; New Orleans, LA. Gastroenterology. 1994;106(4 Suppl 2):A104. PubMed
  • Other Gastrointestinal Conditions

    Clinical References for Neocate related to Other Gastrointestinal Conditions

    • Molnar K, Pinter P, Gyorffy H, et al. Characteristics of allergic colitis in breast-fed infants in the absence of cow's milk allergy. World J Gastroenterol. 2013;19(24):3824-30. Full Text
    • Lee KS, Lee JH. Clinical applications and limitations of a special formula for diarrhea in children. J Korean Med Assoc. 2012;55(6):551-61. Abstract [Full Text in Korean]
    • Drenckpohl D, Vegunta R, Knaub L, et al. Reinfusion of succus entericus into the mucous fistula decreases dependence on parenteral nutrition in neonates. ICAN: Infant Child & Adolescent Nutrition. 2012;4(3):168-74. Abstract
    • de Mattos AP, Ribeiro TC, Mendes PS, et al. Comparison of yogurt, soybean, casein, and amino acid-based diets in children with persistent diarrhea. Nutr Res. 2009;29(7):462-9. PubMed
    • Berni Canani R, Terrin G, Borrelli O, et al. Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn s disease. Dig Liver Dis. 2006;38(6):381-7. PubMed
    • Amadi B, Mwiya M, Chomba E, et al. Improved nutritional recovery on an elemental diet in Zambian children with persistent diarrhoea and malnutrition. J Trop Pediatr. 2005;51(1):5-10. PubMed
    • Amadi B. Role of food antigen elimination in treating children with persistent diarrhea and malnutrition in Zambia. J Pediatr Gastroenterol Nutr. 2002;34 Suppl 1:S54-6. PubMed
    • Hill DJ, Hosking CS. Infantile colic and food hypersensitivity. J Pediatr Gastroenterol Nutr. 2000;30 Suppl:S67-76. PubMed
    • Estep DC, Kulczycki A, Jr. Colic in breast-milk-fed infants: treatment by temporary substitution of neocate infant formula. Acta Paediatr. 2000;89(7):795-802. PubMed
    • Estep DC, Kulczycki A, Jr. Treatment of infant colic with amino acid-based infant formula: a preliminary study. Acta Paediatr. 2000;89(1):22-7. PubMed
  • Other

    Additional References for Neocate

    • de Groof F, Huang L, van Vliet I, et al. Branched-chain amino acid requirements for enterally fed term neonates in the first month of life. Am J Clin Nutr. 2014;99(1):62-70. PubMed
    • Walker HB. A true case story. Microb Ecol Health Dis. 2012;23. Full Text
    • Seffrood E, Schroth M. Nutrition for orally fed children with spinal muscular atrophy. PNPG Building Block for Life. 2012;35(1):5-8.
    • Raimondi F, Spera AM, Sellitto M, et al. Amino acid-based formula as a rescue strategy in feeding very-low-birth-weight infants with intrauterine growth restriction. J Pediatr Gastroenterol Nutr. 2012;54(5):608-12. PubMed
    • Marcus M. Overview on the principles, implementation, and management of the SMA amino acid diet and common complementary therapies in SMA nutrition. PNPG Building Block for Life. 2012;35(1):15-7.
    • Huang L, Hogewind-Schoonenboom JE, van Dongen MJ, et al. Methionine requirement of the enterally fed term infant in the first month of life in the presence of cysteine. Am J Clin Nutr. 2012;95(5):1048-54. Full Text
    • Huang L, Hogewind-Schoonenboom JE, de Groof F, et al. Lysine requirement of the enterally fed term infant in the first month of life. Am J Clin Nutr. 2011;94(6):1496-503. Full Text
    • Ficicioglu C, Hussa C, Yager C, et al. Effect of galactose free formula on galactose-1-phosphate in two infants with classical galactosemia. Eur J Pediatr. 2008;167(5):595-6. PubMed
    • Torgerson TR, Linane A, Moes N, et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology. 2007;132(5):1705-17. PubMed
    • Zlatunich CO, Packman S. Galactosaemia: early treatment with an elemental formula. J Inherit Metab Dis. 2005;28(2):163-8. PubMed
    • Heine RG, Cameron DJ, Chow CW, et al. Effect of amino acid-based formula on crying and fussing in infants with persistent distress. J Pediatr Gastroenterol Nutr. 2002;34(4):464(56).
    • Niggemann B, Binder C, Klettke U, et al. In vivo and in vitro studies on the residual allergenicity of partially hydrolysed infant formulae. Acta Paediatr. 1999;88(4):394-8. PubMed
    • Binder C. Therapeutical use of an elemental diet as an infant formula substitution with a dystrophic infant with CF, anus praeter and hypoproteinemia. ICFNG, 4th Dietitians’ Meeting, XXIInd European Cystic Fibrosis Conference. June 13-19, 1998; Berlin, Germany. 1998;76(WN1-5).
    • Isolauri E. Open or blinded challenges in diagnosing food allergy. J Pediatr Gastroenterol Nutr. 1995;20(4):477. Abstract
  • Eosinophilic Esophagitis (EoE) and related Eosinophilic Gastrointestinal Disorders (EGIDs)

    Clinical References for Neocate related to Eosinophilic Esophagitis (EoE) and other Eosinophilic Gastrointestinal Disorders (EGIDs)

    • Rubinstein E, Lee JJ, Fried A, et al. Comparison of two delivery vehicles for viscous budesonide to treat eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2014;[Epub ahead of print]. PubMed
    • Lucendo AJ, Arias A, Gonzalez-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol. 2013;131(3):797-804. Abstract
    • Kalach N, Colson D, Soulaines P, et al. 3-Months elimination diet in childhood EoE: nutritional and immunological aspects. 2013 AAAAI Annual Meeting. February 22-26, 2013; San Antonio, TX. J Allergy Clin Immunol. 2013;131(2):AB181(644). Abstract
    • Hait EJ, Lee J, Fried A, et al. Neocate® Nutra is as effective as sucralose as a delivery vehicle for oral viscous budesonide to treat eosinophilic esophagitis in children. Full Text
    • Groetch M, Nowak-Wegrzyn A. Practical approach to nutrition and dietary intervention in pediatric food allergy. Pediatr Allergy Immunol. 2013;24(3):212-21. PubMed
    • Henderson CJ, Abonia JP, King EC, et al. Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2012;129(6):1570-8. PubMed
    • Gorter RR, Heij HA, van der Voorn JP, et al. Eosinophilic esophagitis after esophageal atresia: is there an association? Case presentation and literature review. J Pediatr Surg. 2012;47(6):e9-13. PubMed
    • Haas AM. Development, mealtime dynamics and nutrition: Use of an amino acid-based semi-solid supplement in a child with eosinophilic esophagitis. Clinical Nutrition Week 2011. Vancouver, B.C., Canada. Nutr Clin Pract. 2011;26(1):E19(N36). Abstract
    • Basilious A, Liem J. Nutritional management of eosinophilic gastroenteropathies: case series from the community. Allergy Asthma Clin Immunol. 2011;7:10. Full Text
    • Spergel JM, Brown-Whitehorn TF, Beausoleil JL, et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr. 2009;48(1):30-6. PubMed
    • Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4(9):1097-102. PubMed
    • Chehade M, Magid MS, Mofidi S, et al. Allergic eosinophilic gastroenteritis with protein-losing enteropathy: intestinal pathology, clinical course, and long-term follow-up. J Pediatr Gastroenterol Nutr. 2006;42(5):516-21. PubMed
    • Spergel JM, Andrews T, Brown-Whitehorn TF, et al. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95(4):336-43. PubMed
    • Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3(12):1198-206. PubMed
    • Sundaram S, Sunku B, Nelson SP, et al. Adherent white plaques: an endoscopic finding in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2004;38(2):208-12. PubMed
    • Ko J, Magid MS, Benkov KJ, et al. A 17-month-old boy with periorbital swelling. Ann Allergy Asthma Immunol. 2004;93(3):220-6. PubMed
    • Markowitz JE, Spergel JM, Ruchelli E, et al. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98(4):777-82. PubMed
    • Spergel JM, Beausoleil JL, Mascarenhas M, et al. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002;109(2):363-8. PubMed
    • Ruchelli E, Wenner W, Voytek T, et al. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol. 1999;2(1):15-8. PubMed
    • Kelly KJ, Lazenby AJ, Rowe PC, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503-12. PubMed

Educational Courses/Modules

  • FARE’s Pediatric Food Allergy Course

    This comprehensive 9-month course led by food allergy experts, Marion Groetch, MS, RDN and Carina Venter, PhD, RD, will cover topics such as diagnosis and management of pediatric food allergies. Upon successful completion dietitians will be prepared to provide up-to-date and evidence-based care and medical nutrition therapy to pediatric patients with food allergies, hold a FARE Certificate of Training in Pediatric Food Allergy and earn 55 CPEUS. Nutricia North America has been proudly supporting FARE to bring you this course since its inauguration in 2020.

  • NASPGHAN Nutrition University (N2U)

    A specialized nutrition course designed for senior pediatric gastroenterology fellows and junior faculty. This educational activity covers topics related to the practice of pediatric gastroenterology and nutrition and has been proudly supported by Nutricia North America since 2012.